30
Jan
Antibiotic Loaded Cement In Orthopedic Surgery A Review. Gram positive coverage a. Gram negative coverage a. Since the early 1970s the use of antibiotics in bone cement has been widespread. In intramedullary infections antibiotic bone cement nails or antibiotic cement nails ACNs are preferable.
Abstract Antibioticloaded bone cement ALBC is broadly used to treat orthopaedic infections based on the rationale that highdose local delivery is. Antibiotic loaded bone cement can be customized intraoperatively to different shapes and forms. In a study of 684 patients with total hip arthroplasty infection they obtained a 71 success rate after one-step prosthesis replacement with gentamicin-loaded cement but no systemic antibiotic treatment. Since the early 1970s the use of antibiotics in bone cement has been widespread. In a subsequent study by the same group a similar treatment program yielded a 77 success rate. Aminoglycoside-loaded bone cement ALBC implants are frequently used in orthopedic surgery.
In a subsequent study by the same group a similar treatment program yielded a 77 success rate.
In a study of 684 patients with total hip arthroplasty infection they obtained a 71 success rate after one-step prosthesis replacement with gentamicin-loaded cement but no systemic antibiotic treatment. The use of high-dose antimicrobial-loaded bone cement is generally considered safe. Despite the widespread use of the antibiotic-loaded bone cement in orthopedics many issues are still unclear or controversial. Espehaug et al 1997. The PMMA bone cement is a good carrier for sustained antibiotic release in the site of infection. When given parenterally optimum peak serum concentration of tobramycin is between 6-10 µgmL and trough concentrations should be less than 2 µgmL.