18
May
Causes Of Aneuploidy In Humans. Klinefelter syndrome is the most common sex chromosome aneuploidy in humans. Since the identification of the first human aneuploid conditions nearly a half-century ago a great deal of information has accrued on its origin and etiology. People suffering from chronic myeloid leukemia CML a cancer of the white blood cells frequently harbor cells containing the so-called Philadelphia chromosome. This condition called aneuploidy is most often caused by some error resulting in an unequal distribution of chromosomes to the daughter cells.
However the debate is ongoing whether aneuploidy is rather a by-product or a trigger of tumorigenesis. It has been unclear how common chromosomal mosaicism is among human embryos. Preclinical evidence of PGD-A indicates that the selection and transfer of euploid embryos during ART should improve clinical outcomes. Most aneuploid eggs cannot develop to term upon fertilization making aneuploidy in eggs a leading cause of miscarriages and infertility. Since the identification of the first human aneuploid conditions nearly a half-century ago a great deal of information has accrued on its origin and etiology. We examined the effects of aneuploidy on primary mouse cells by generating a series of cell lines that carry an extra copy of one of four mouse chromosomes.
This condition called aneuploidy is most often caused by some error resulting in an unequal distribution of chromosomes to the daughter cells.
Klinefelter syndrome is the most common sex chromosome aneuploidy in humans. Aneuploidy is a leading cause of pregnancy loss and birth defects in humans and in vitro fertilisation clinics often choose to discard embryos with aneuploidy rather than implanting them. When fertilized these eggs give rise to aneuploid embryos that usually fail to develop. In human female meiosis chromosomes frequently segregate incorrectly resulting in eggs with an abnormal number of chromosomes. It represents the most frequent cause of hypogonadism and infertility in men. Fourth in humans adenomas with mild-to-moderate dysplasia or atypical ductal hyperplastic lesions exhibit only low-grade aneuploidy B omme et al.