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Difference Between Extrinsic And Intrinsic Coagulation Pathways. Difference Between Intrinsic and Extrinsic Pathway in Blood Clotting Definition. Difference between intrinsic and extrinsic coagulation pathways How do the kidneys function in maintaining homeostasis in fluid volume. Describe the feedback loops used and the actions upon glomerular filtration tubular reabsorption and secretion. Intrinsic sounds like the important pathway that happens in the body and extrinsic sounds like one that might happen in the lab or outside the body.
The clotting cascade occurs through two separate pathways that interact the intrinsic and the extrinsic pathway. Intrinsic pathway arises if the endothelium is damaged blood contacting collagen platelets being damaged by cut edges of the vessel wall ultimately activates the pathway Extrinsic pathway arises if only cells surrounding the blood vessel are damaged TF leaks in from the damaged cells and into the blood. Requires a component extrinsic to blood. Conversion of prothrombin into thrombin. 2001B07 Explain the main differences between the intrinsic and the extrinsic pathways of coagulation. The extrinsic pathway gets turned off after that and the intrinsic pathway takes over but at that point it doesnt matter.
The two pathways were named that way because of the way blood clots in a.
The intrinsic pathway is activated through exposed endothelial collagen and the extrinsic pathway is activated through tissue factor released by endothelial cells after external damage. Requires a component extrinsic to blood. In five paired experiments the KL for factor X activation by intrinsic pathway components factor IXa VIII was fold lower than the corresponding parameter for activation via the extrinsic pathway Table 11. The two pathways were named that way because of the way blood clots in a. 2001B07 Explain the main differences between the intrinsic and the extrinsic pathways of coagulation. Both pathways end up in a common pathway.