19
May
Endogenous Ligand For Cannabinoid Receptors. The enzymatic synthesis of anandamide in bovine brain tissue was examined by incubating brain membranes with 14Cethanolamine and arachidonic acid. 2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors CB1 and CB2. The enzyme responsible for this hydrolysis was solubilized partially purified from the microsomes of porcine brain and referred to as anandamide amidohydrolase. 2-AG is rapidly formed from arachidonic acid-containing phospholipids through increased phospholipid metabolism such as enhanced inositol phospholipid turnover in various tissues and cells upon stimulation.
The enzymatic synthesis of anandamide in bovine brain tissue was examined by incubating brain membranes with 14Cethanolamine and arachidonic acid. THC as well as the two major endogenous compounds identified so far that bind to the cannabinoid receptors anandamide and 2-arachidonylglycerol 2-AG produce most of their effects by binding to both the CB 1 and CB 2 cannabinoid receptors. Sugiura et al 1995. The cannabinoid CB1 and CB2 receptors their endogenous ligands the endocannabinoids the best studied of which are anandamide and 2-arachidonoylglycerol 2-AG and the proteins that regulate the levels and activity of these receptors and ligands. 2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors CB1 and CB2. In analogy with the endorphins they can be referred to as.
2-Arachidonoylglycerol is an endogenous ligand for the cannabinoid receptors CB1 and CB2.
In analogy with the endorphins they can be referred to as. THC as well as the two major endogenous compounds identified so far that bind to the cannabinoid receptors anandamide and 2-arachidonylglycerol 2-AG produce most of their effects by binding to both the CB 1 and CB 2 cannabinoid receptors. These compounds are synthesized by neuronal cells and inactivated through re-uptake and enzymatic hydrolysis by both neurons and astrocytes. The enzymatic synthesis of anandamide in bovine brain tissue was examined by incubating brain membranes with 14Cethanolamine and arachidonic acid. The enzyme responsible for this hydrolysis was solubilized partially purified from the microsomes of porcine brain and referred to as anandamide amidohydrolase. In addition to the.