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Aug
Ivf Double Stimulation Protocol. The double stimulation or DuoStim protocol combines conventional follicular phase stimulation together with luteal phase stimulation so that two oocyte retrieval procedures can be performed. Some patients may develop only very few eggs and the stimulation will have to be repeated while others may over-react with a risk of a. This article describes a revised ovarian stimulation protocol DuoStim for fertility preservation in female oncology patients which aims to maximise the number of gametes obtained with subsequent improvement in cumulative birth rate without delaying cancer treatment. There are several options for ovarian stimulation but they all include a series of different medications taken over several daysweeks called a stimulation protocol.
The double stimulation or DuoStim protocol combines conventional follicular phase stimulation together with luteal phase stimulation so that two oocyte retrieval procedures can be performed. Controlled ovarian hyper-stimulation using antagonist protocol will be used. This step will be done twice in two different cycles In each cycle. Whether this approach yields better results to two cycles of conventional COH is. Stimulation with 225-375 IU of gonadotropins will be started day 2-3 of menses after vaginal ultrasound confirming the absence of. Now a new observational study of a dual stimulation protocol appears to offer a very promising strategy.
Double stimulation and subsequent cryopreserved embryo transfer is a promising approach both for patients with POR especially for the cases that repeatedly did not have oocytes retrieved or viable embryos using conventional IVF.
Whether this approach yields better results to two cycles of conventional COH is. Double stimulation IVF DuoStim DuoStim method is based on double stimulation during the same cycle. As mentioned above double stimulation during the follicular and luteal phases in the same menstrual cycle provided more opportunities to retrieve oocytes in poor responders with the resulting embryos having similar development potential. This technique was abandoned due to low success rates in subsequent attempts. Unlike traditional IVF protocols where patients undergo a single round of ovarian stimulation with fertility drugs and egg retrieval in one menstrual cycle in the DuoStim protocol patients undergo two rounds of ovarian stimulation and two egg retrievals in the same menstrual cycle. This study is a prospective before after clinical trial to investigate the efficacy of double stimulations during both the follicular and luteal phases in patients with poor ovarian response undergoing IVF and intracytoplasmic sperm injection ICSI cycles.