16
Jun
P53 Negative Serous Carcinoma. One of the main genetic features of this disease is TP53 mutation. Ovarian carcinomas which show a SET pattern of high grade serous carcinoma. Uterine papillary serous adenocarcinomas showed significantly higher p53 overexpression than uterine endometrioid adenocarcinomas 1000 versus 610 p. Moreover a small number of serous carcinomas are p53 negative and some are positive for ER and PR.
Strong and diffuse immunoexpression of p53 is generally interpreted as likely indicating a TP53 gene mutation. Positivity for p53 was strong and diffuse 100 of tumor cells in 5 uterine tumors and in 3 ovarian tumors. Diffuse positive overexpression 97 and diffuse negative complete absence. 98 The diffuse p53 positivity and negativity are believed to be associated with gain-of-function and loss-of. Most originate in fallopian tube. These features are best characterized as high grade serous carcinoma which displays a SET solid pseudoendometrioid or transitional pattern.
The immunoprofile that correlates with wild-type TP53 however is not as clear.
Estrogen receptor and progesterone receptor expression is negative. A wild-type pattern of p53 expression ie p53 staining in scattered nuclei of tumor cells is typical of papillary ECa of intermediate grade while serous carcinoma is characterized by aberrant. P53 immunohistochemistry IHC is widely used as a surrogate for TP53 mutation but its accuracy has not been established. High grade serous ovarian cancer is characterised by high initial response to chemotherapy but poor outcome in the long term due to acquired resistance. The immunoprofile that correlates with wild-type TP53 however is not as clear. Nuclear overexpression of p53 whereas six tumors 15 were p53 negative.