11
Aug
Use Of Starch In Tablet Formulation. Relatively few are in common usage today. Therefore the historical claim of Leach claiming the starch having very limited obstructive power for the drug release seems to be not entirely valid. It may serve as diluent binder and disintegrating agent. In addition the Starch 1500 in the formulation was replaced with further ratios of MCC and lactose Tables 1 2.
The most common use of starch as a pharmaceutical excipient is as binder and disintegrant in the formulation of tablets and other solid dosage forms. Selection of the quantity required in a given system is determined by optimization studies using parameters such as granule friability tablet. Granulation of rice starch changed it into a potential filler-binder in tablets prepared by direct compression. Traditionally starch has been the disintegrant of choice in tablet formulations and it is still widely used. Modification is a means of enhancing the functionality. Starches are extensively used in the pharmaceutical industry especially as excipients in tablet formulation.
Next we employed a central composite design for 2 factors namely corn starch and partly pregelatinized starch in order to design granules suited for orally disintegrating tablets composed of D-mannitol corn starch or partly pregelatinized starch.
Rice starch showed much better comp Native starch in tablet formulations. Therefore the historical claim of Leach claiming the starch having very limited obstructive power for the drug release seems to be not entirely valid. For example starch is a multi-functional excipient for tablets. Moreover intra granular starch in wet granulations is not as effective as dry starch. Pregelatinized maize starch is commonly used as a binder- disintegrant in immediate release tablet formulations but it was also considered for sustained release formulations 1-3. It is now widely acknowledged that starches in their native form have functional limitations.