20
Dec
What Is Synonymous Mutation. Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Synonymous mutation rate Ks Mutationssubstitutions of DNA base pairs that do not result in a change of amino acid sequence. Synonymous mutations sometimes called silent mutations are now widely acknowledged to be able to cause changes in protein expression. The term synonymous mutation is also applied to the change of a stop codon into another stop codon.
A large repertoire of both experimental and bioinformatic methods has been developed to understand the effects of synonymous variants. Synonymous codon changes which do not alter protein sequence were previously thought to have no functional consequence. Synonymous mutations sometimes called silent mutations are now widely acknowledged to be able to cause changes in protein expression. The term synonymous mutation is also applied to the change of a stop codon into another stop codon. This Wikipedia page and this blog post define a silent mutation as any mutation that does not have any phenotypic effects and defines a synonymous substitution as a point substitution to a degenerate codon anywhere in the genome as far as I can tell. After the base substitution while each codon into another codon but because of codon degeneracy thereby changing the former the amino acid encoded by the codon change Therefore the mutation effect does not occur.
Synonymous changes may not be neutral because certain codons are translated more efficiently faster andor.
Also known as a silent mutation. Synonymous changes may not be neutral because certain codons are translated more efficiently faster andor. After the base substitution while each codon into another codon but because of codon degeneracy thereby changing the former the amino acid encoded by the codon change Therefore the mutation effect does not occur. A codon in RNA is a set of three nucleotides that encode a specific amino acid. Synonymous mutations sometimes called silent mutations are now widely acknowledged to be able to cause changes in protein expression. Also known as a substitution mutation.